MACULAR DEGENERATION MODELS

LASER-INDUCED CHOROIDAL NEOVASCULARIZATION

The laser-induced choroidal neovascularization (CNV) model is a classic animal model used to examine the efficacy of compounds in the prevention of neovascularization. This model is currently available for use in mice and rats.
 

 

SOD1-/- MICE (UNDER DEVELOPMENT)

These mice are genetic knockouts for the Sod1 gene. They present with a retinal phenotype commonly associated with non-exudative age-related macular degeneration and geographic atrophy. This includes drusen formation by 6 months of age that increases ~10-fold by 12 months of age, loss of photoreceptor cells, and subsequent decrease in retinal visual function.